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Multistate Outbreak of Fungal Infection Associated with Injection of Methylprednisolone Acetate Solution from a Single Compounding Pharmacy — United States, 2012

Early Release 

October 12, 2012 / 61(Early Release);1-4 

On September 18, 2012, the Tennessee Department of Health was alerted by a clinician regarding a patient with culture-confirmed Aspergillus fumigatus meningitis diagnosed 46 days following epidural steroid injection at a Tennessee ambulatory surgical center. By September 27, the initial investigation, carried out by the Tennessee Department of Health in collaboration with CDC and the state health department in North Carolina, had identified an additional eight patients with clinically diagnosed, culture-negative meningitis. As of October 10, a multistate investigation led by CDC in collaboration with the Food and Drug Administration and state and local health departments had identified 137 cases and 12 deaths in 10 states associated with this outbreak.

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