Antimicrobial Agent Use
Antimicrobial Prophylaxis for Surgery
Antimicrobial Resistance
Antimicrobial Stewardship
Neutropenic Patients with Cancer
Outpatient Parenteral Anti-infective Therapy (OPAT)
Vancomycin
Antimicrobial Prophylaxis for Surgery
"Quality Standard for Antimicrobial Prophylaxis in Surgical Procedures"
Clinical Infectious Diseases 1994; 18:422-7
The objectives of this quality standard are (1) to provide an implementation mechanism that will facilitate the reliable administration of prophylactic antimicrobial agents to patients undergoing operative procedures in which such a practice is judged to be beneficial and (2) to provide a guideline that will help local hospital committees formulate policies and set up mechanisms for their implementation.
The original Therapeutic Guidelines on Antimicrobial Prophylaxis in Surgery was published in 1999. The American Society of Health-System Pharmacists, Infectious Disease Society of America, Surgical Infection Society, and Society of Healthcare Epidemiology of America have collaborated to revise this current draft of the therapeutic guideline to reflect the current knowledge on antimicrobial prophylaxis in surgery since 1999. Sections on the revisied therapeutic guideline are open for public comment.
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*Projected Publication, Fall 2010
Antimicrobial Resistance
"Guidelines for the Prevention of Antimicrobial Resistance in Hospitals"
Clinical Infectious Diseases 1997; 25:584-99
Antimicrobial resistance results in increased morbidity, mortality, and costs of health care. Prevention of the emergence of resistance and the dissemination of resistant microorganisms will reduce these adverse effects and their attendant costs. Appropriate antimicrobial stewardship that includes optimal selection, dose, and duration of treatment, as well as control of antibiotic use, will prevent or slow the emergence of resistance among microorganisms.
Antimicrobial Stewardship
"Guidelines for Developing an Institutional Program to Enhance Antimicrobial Stewardship"
Clinical Infectious Diseases 2007; 44: 159-77
This document presents guidelines for developing institutional programs to enhance antimicrobial stewardship, an activity that includes appropriate selection, dosing, route, and duration of antimicrobial therapy. The primary goal of antimicrobial stewardship is to optimize clinical outcomes while minimizing unintended consequences of antimicrobial use, including toxicity, the selection of pathogenic organisms (such as Clostridium difficile), and the emergence of resistance. Thus, the appropriate use of antimicrobials is an essential part of patient safety and deserves careful oversight and guidance. more »
Neutropenic Patients with Cancer
"2002 Guidelines for the Use of Antimicrobial Agents in Neutropenic Patients with Cancer"
Clinical Infectious Diseases 2002; 34:730–751
This article, prepared by the Infectious Diseases Society of America (IDSA) Fever and Neutropenia Guidelines Panel, updates guidelines established a decade ago by the Infectious Disease Society of America for the use of antimicrobial agents to treat neutropenic patients with unexplained fever. more »
Neutropenia 1997 Guideline (PDF)
*Projected Publication, Winter 2011
Outpatient Parenteral Anti-Infective Therapy (OPAT)
"Practice Guidelines for Outpatient Parenteral Antimicrobial Therapy"
Clinical Infectious Diseases 2004; 38:1651–1672
These guidelines were formulated to assist physicians and other health care professionals with various aspects of the administration of outpatient parenteral antimicrobial therapy (OPAT). Although there are many reassuring retrospective studies on the efficacy and safety of OPAT, few prospective studies have been conducted to compare the risks and outcomes for patients who receive treatment as outpatients rather than as inpatients. Because truly evidence-based studies are lacking, the present guidelines are formulated from the collective experience of the committee members and advisors from related organizations. more »
OPAT 1997 Guideline (PDF)
Vancomycin
"Vancomycin Therapeutic Monitoring: Review and Recommendations from the ASHP, IDSA and SIDP Task Force"
Am J Health-Syst Pharm. 2009; 66:82-98
Vancomycin is a glycopeptide antibiotic that has been in clinical use for nearly 50 years as a penicillin alternative to treat penicillinase-producing strains of Staphlococcus aureus. It is one of the most widely used antibiotics in the United States for the treatment of serious gram-positive infections involving methicillin-resistant S. aureus (MRSA). more »
