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Hepatitis C

Welcome to Hepatitis C Management Discussion Board! The Hepatitis C Management Discussion Board provides Infectious Disease Clinicians a platform to connect with colleagues to exchange information, case studies, complications, and new developments on matters concerning hepatitis C treatment and management. Certain case studies will be developed into clinical vignettes and will be available to Infectious Disease Clinicians for future reference. Please be respectful of all participants and their respective comments. Please read our Terms of Use and Discussion Forum Guidelines.


Any diagnostic or therapeutic recommendations and all opinions presented are those of the individual contributor. They do not necessarily represent the views of IDSA. The reader assumes all risks in using this information. The IDSA Hepatitis C Discussion Forum is in full compliance with HIPPA. IDSA bears no responsibility for the accuracy of participant comments and will bear no legal liability for discussion results.

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Clinicians Wait for Next Wave of Hepatitis C Antivirals - By: Debra Gordon
Posted: Tuesday, June 11, 2013 3:43 PM
Joined: 2/20/2013
Posts: 40

"It’s been just two years since the protease-inhibitors boceprevir (Victrelis) and telaprevir (Incivek), the first in what was described as a “disease-changing” class of drugs for the treatment of hepatitis C (HCV), were approved. Yet many clinicians already consider the original directly acting antivirals (DAAs) obsolete.

Although clinical trials showed they increase the cure rate from the 50% seen with the standard of care peginterferon-alpha (PEG-IFN) and ribavirin(Drug information on ribavirin) (RBV), to about 75% in patients chronically infected with HCV-1, their high rate of adverse effects, high pill burden, drug-drug interactions, low response in certain populations, and the need to administer them in conjunction with PEG-IFN and RBV has significantly limited their use.1 The reality is that clinicians are abandoning the drugs as they wait for the first in a new wave of HCV therapies expected to hit the market in late 2013 and 2014."


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