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IDSA Clinical Practice Guidelines are developed by a panel of experts who perform a systematic review of the available evidence and use the GRADE process to develop evidence-based recommendations to assist practitioners and patients in making decisions about appropriate health care for specific clinical circumstances.

IDSA Clinical Guidance documents are developed based on a comprehensive (but not necessarily systematic) review of the available evidence, coupled with experience of clinical and research experts on the topic. They do not include a formal grading of the evidence. Over time, IDSA Guidance documents may be transitioned to a clinical practice guideline.

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